Modulation of cytochrome biosynthesis in yeast by antimetabolite action of levulinic acid

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15 صفحه اول

Antimetabolite poisoning of cofactor biosynthesis.

The lack of new antibiotics coupled with the increased prevalence of multidrugresistant bacterial pathogens is cause for great concern (Wright, 2012). The genomics revolution predicted a new era in antibiotics discovery with the delivery of an abundance of conserved and essential targets (Payne et al., 2007). However, target-based approaches for antibacterial discovery have proven quite challen...

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Levulinic acid

THE TITLE COMPOUND (SYSTEMATIC NAME 4-oxo-penta-noic acid), C5H8O3, is close to planar (r.m.s. deviation = 0.0762 Å). In the crystal, the mol-ecules inter-act via O-H⋯O hydrogen bonds in which the hy-droxy O atoms act as donors and the ketone O atoms in adjacent mol-ecules as acceptors, forming C(7) chains along [20-1].

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ژورنال

عنوان ژورنال: Journal of Bacteriology

سال: 1979

ISSN: 0021-9193,1098-5530

DOI: 10.1128/jb.138.3.799-804.1979